Lymphocyte cytotoxicity to autologous hepatocytes in alpha 1-antitrypsin deficiency.

Lymphocyte cytotoxicity to autologous hepatocytes in alpha 1-antitrypsin deficiency.

To investigate the possible role of cell mediated cytotoxicity in the pathogenesis or perpetuation of liver damage associated with alpha 1-antitrypsin (AAT) deficiency, peripheral blood lymphocytes (PBL) from 13 children with PiZZ phenotype who had had liver disease in infancy were incubated with autologous hepatocytes in a microcytotoxicity assay. There was a clear trend for cytotoxicity to in...

Lymphocyte cytotoxicity to autologous hepatocytes in alphal - antitrypsin deficiency

To investigate the possible role of cell mediated cytotoxicity in the pathogenesis or perpetuation of liver damage associated with alpha1-antitrypsin (AAT) deficiency, peripheral blood lymphocytes (PBL) from 13 children with PiZZ phenotype who had had liver disease in infancy were incubated with autologous hepatocytes in a microcytotoxicity assay. There was a clear trend for cytotoxicity to inc...

Lymphocyte cytotoxicity for autologous hepatocytes

Lymphocyte cytotoxicity for autologous hepatocytes

Lymphocyte cytotoxicity for autologous hepatocytes.